‘Lightning bolts’ in the brain show learning in action

first_imgShare on Twitter Gan, a professor at NYU Langone and its Skirball Institute for Biomolecular Medicine, says, “we have long wondered how the brain can store new information continuously throughout life without disrupting previously acquired memories. We now know that the generation of calcium spikes in separate branches of nerve cells is critical for the brain to encode and store large quantities of information without interfering with each other.”Lead study investigator Joseph Cichon, a neuroscience doctoral candidate at NYU Langone, says their discoveries could have important implications for explaining the underlying neural circuit problems in disorders like autism and schizophrenia. Cichon says the team’s next steps are to see if calcium ion spikes are malfunctioning in animal models of these brain disorders.Among the study’s key findings was that learning motor tasks such as running forward and backward induced completely separate patterns of lightning bolt-like activity in the dendrites of brain cells. These lightning bolts triggered a chain-like reaction, which changed the strength of connections between neurons.The study also identified a unique cell type in the brain that controlled where the lightning bolts were generated. When these cells were turned off, lightning bolt patterns in the brain were disrupted, and as a result, the animal lost the information it had just learned. Share Researchers at NYU Langone Medical Center have captured images of the underlying biological activity within brain cells and their tree-like extensions, or dendrites, in mice that show how their brains sort, store and make sense out of information during learning.In a study to be published in the journal Nature online March 30, the NYU Langone neuroscientists tracked neuronal activity in dendritic nerve branches as the mice learned motor tasks such as how to run forward and backward on a small treadmill. They concluded that the generation of calcium ion spikes — which appeared in screen images as tiny “lightning bolts” in these dendrites — was tied to the strengthening or weakening of connections between neurons, hallmarks of learning new information.“We believe our study provides important insights into how the brain deals with vast amounts of information continuously as the brain learns new tasks,” says senior study investigator and neuroscientist Wen-Biao Gan, PhD. Share on Facebookcenter_img LinkedIn Pinterest Emaillast_img read more

Swire orders second windfarm installation vessel

first_imgThe new vessel, Pacific Osprey, will be the same specification as Pacific Orca, currently under construction atSamsung and delivering in 2012. Pacific Osprey is scheduled to arrive in Europe in early 2013 and will be used for the installation of wind turbine generators for Dan Tysk Offshore Wind in the German North Sea. Pacific Orca, which was originally contracted by the Dan Tysk project, will be committed to another European project. The re-allocation of Pacific Orca and Pacific Osprey between projects provides the parties with a better alignment between the delivery dates of the vessels and the commencement of their initial contracts, says Swire.The Swire Blue Ocean windfarm installation vessel design focuses on safety, efficiency and reliability and will provide customers with a significantly improved operating weather window, claims swire. The advanced specification features a usable deck area in excess of 4,000 sq m, DP 2 station keeping, a 1200 tonne capacity crane, a total jackable weight of 8,400 tonnes and a transit speed of 13 knots. The vessel is well suited for the installation of both wind turbines and foundations.”Exercising the option to build our second Windfarm Installation Vessel is an important milestone for the company and underlines our commitment to the offshore wind industry”, Lars Blicher, general manager and director of Swire Blue Ocean, commented. “The industry, quite rightly, has high expectations of the levels of safety, efficiency and operating performance required from vessel owners as it moves towards increasingly challenging projects. We are fully focused on ensuring these objectives are met.” For more information, please contact Swire Blue Ocean A/S in Denmark, tel +45 7026 3133 – attention Ms Rikke V. Stoltz, Business Development Manager & Director, email [email protected] or visitwww.swireblueocean.comlast_img read more

Linder Myers saviour looks to the future

first_imgThe new chief executive of rescued Manchester firm Linder Myers has insisted he can turn the business around. Tony Stockdale (pictured), chair of legal business adviser Assure Law, led the takeover of the firm last month, saving it from entering administration.Stockdale revealed to the Gazette that a separate company, Assure Law Finance, has ploughed a seven-figure sum into Linder Myers to help restructure the firm’s debts.Stockdale said the firm has always been profitable but suffered from a rapid acquisitions spree which saw five new firms bought in the last three years.‘This is and was a good business,’ said Stockdale. ‘Clearly it has run into difficulty as it has grown, which brought challenges in terms of integration and creating one business.‘Some of the teams have joined recently and there is work to be done in building relationships. But there is confidence in the business.’Stockdale, an accountant, formed Assure Law last year with people from different professional sectors.The firm, which has 20 staff and is recruiting, aims to ‘instil a business focus’ into law firms and create an environment to make the most of healthy profits and turnover.Former managing partner Bernard Seymour has become senior partner of Linder Myers, with Stockdale and three other members of his team forming the firm’s management. Stockdale will be at the helm for ‘at least 18 months’, during which time he is ‘in effect on a consultancy contract from Assure Law’.The immediate priority will be to improve the IT infrastructure and address levels of debt built up in recent years, he said.Stockdale said there are no plans to cut any of Linder Myers’ 300 staff, but the nature of the business and its financial situation will be assessed over the next eight weeks.Assure Law will continue to look for other legal businesses either to advise or to take a more hands-on role.last_img read more

Waite Park City Council Looks to Approve Pickleball Court Plans

first_img 360p Visit Advertiser website GO TO PAGE Skip 720p HD WAITE PARK — Waite Park residents will be albe to play Pickleball games as soon as this fall.During last (Monday) night’s city council meeting, the council approved plans for six pickleball courts to be built at River’s Edge Park.Waite Park Public Works Director Bill Schluenz says with the approval they will now begin collecting bids for the project, which is estimated at $470,000. About Connatix V56892 The courts are part of Phase 3 of improvements to the park and will be built just south of the Splash Pad at the corner of 3rd Street and 10th Avenue.Schluenz says they have a bid date of June 30th and if all goes well construction will begin this summer with completion expected by September or October.center_img 1/1 1080p HD Auto (360p) About Connatix V56892last_img read more

Real Sociedad Sign Mikel Merino In €12m Deal

first_imgRelatedSpanish Star Signs For Newcastle United In Permanent DealOctober 13, 2017In “England”Dubravka Makes Newcastle United Deal PermanentMay 31, 2018In “England”Yoshinori Muto Completes Newcastle United MoveAugust 2, 2018In “England” Real Sociedad have signed Spanish midfielder Mikel Merino from Premier League side Newcastle United.The 22-year-old has put pen to paper on a five-year deal after the Spanish La Liga side agreed to pay the €13m (£10m) release clause in his Newcastle United contract.Mikel Merino initially joined Newcastle United from Borussia Dortmund on loan last summer before the move was made permanent in October 2017.On his transfer to Spain, Newcastle United manager Rafael Benitez revealed that the move was mainly because of his lack of playing time last season.In his words, Benitez said: “It was a pity because obviously he wanted to play more football.”“He is a young player and he struggled to get back into the team because [Mo] Diame and [Jonjo] Shelvey were doing so well.“That meant Merino didn’t get much game-time, then we had three or four Spanish clubs who were interested in him.“In the end it was something we couldn’t control because he decided to go.“We knew that could happen, so we had to be prepared – and in the end we were.” The former Real Madrid and West Ham United boss concluded.last_img read more